• The present study has several limitations First

  2019-09-02

  

  The present study has several limitations. First, it was a retrospective study conducted in a single institution. For the prognostic model, it is necessary to assess whether the model actually improves predictive power over other prognostic tools, such as the pathologic TNM stage, in additional mult

• In this study SOX expression was not associated with RFS

  2019-09-02

  

  In this study, SOX2 expression was not associated with RFS. We believe there are a couple of reasons for this observation. First, this result might be influenced by the inconsistency of adjuvant treatment after surgery because of the retrospective analysis. Second, in other carcinomas such as uroth

• Some limitations of this study exist that must be

  2019-08-26

  

  Some limitations of this study exist that must be taken into account: first, it is a monocentric study; second, the sample size may limit the statistical power, though, it should be noted that, this is the largest study to describe detailed lymph node metastasis status in driver mutant NSCLC; third,

• In the current study PC cells

  2019-08-26

  

  In the current study, PC-9 Conessine alone did not form spheroids, but the addition of CAFs successfully promoted spheroid/organoid formation (Table 1). The success rate of spheroid/organoid formation was 40% when equal numbers of CAFs and PC-9 cells (1 × 104) were mixed. However, the addition of 1

• False perception of cure another leading cause of abandonmen

  2019-08-16

  

  False perception of cure, another leading cause of abandonment during consolidation in the present study, was probably due to the improved general condition of the child in remission post-induction and the associated fear of another bout of toxic chemotherapy. Similarly, after interim maintenance, m

• Early age at onset of cancer cancer tumor type cancer

  2019-08-11

  

  Early age at onset of cancer, cancer/tumor type, cancer laterality, multiple primary tumors, coexistence of an associated inherited disorder, family history, cancer history of affected family members, degree of relatedness to the patient, and consanguinity have all been reported as eligibility crite

• Emotional distress is not a

  2019-08-11

  

  Emotional distress is not a static situation. Women who survive breast cancer go through many different stages, which may influence their emotional welfare and mental health. Nearly 30% of breast cancer survivors experience chronic pain five years after treatment. Pain and depression are common symp

• PC and BTC are estimated to be th and

  2019-08-11

  

  PC and BTC are estimated to be 7th and 16th, respectively, most common causes of cancer death in males, and 8th and 13th in females worldwide [2]. The age-standardised mortality rate (ASRm, per 100,000) for PC was slightly higher in males than females (4.8 vs. 3.4); but the ASRm for BTC was similar

• Dr E Shenkman s effort for this publication

  2019-08-11

  

  Dr. E. Shenkman’s effort for this Concanamycin A publication was supported, in part, by the University of Florida Clinical and Translational Science Institute, which is supported in part by the National Center for Advancing Translational Sciences of the National Institutes of Health under award numb

• In our analysis treatment at a bone tumour centre was

  2019-08-11

  

  In our analysis, treatment at a bone tumour centre was associated with better survival in patients with high-grade central osteosarcoma. Based on our data, no specification was possible for the different treatment modalities. Treatment is therefore defined as multidisciplinary surgical and systemic

• br Functional implication of PAK mediated pathways in the

  2019-07-30

  

  Functional implication of PAK-mediated pathways in the brain The majority of the literature related to PAKs is on cancer biology, in particular the role of these kinases in promoting cancer cell motility and metastatic progression. Being central components of the signal transduction cascades, PAK

• In this work we also analysed

  2019-07-30

  

  In this work we also analysed the effect of two variants found in OPTN promoter: rs3829923 – that was present in 13 patients and not in any of the controls tested - but that after the association study was found not to be associated with PDB (uncorrected p-value=1); and RV −9906 - a rare variant fou

• Akt signaling is involved in

  2019-07-24

  

  Akt signaling is involved in multiple cellular activities, including cell proliferation and metastasis [17]. The phosphorylation of Akt on serine 473 is involved in the growth and invasion of some cancers, including gastric cancer [18]. However, it is still unknown whether the activation of Akt is i

• Interleukin receptor IL R associated

  2019-07-24

  

  Interleukin-1 receptor (IL-1R)-associated kinase (IRAK) is a family of Ser/Thr kinases involved in signaling of innate immune response mainly induced by the TLR/IL-1R family [27]. The family comprises four IRAK molecules, namely IRAK1, IRAK2, IRAK3 (IRAKM), and IRAK4. IRAK1, IRAK2, and IRAK4 are pos

• In an energy demanding process CL remodeling shapes

  2019-07-11

  

  In an energy demanding process, CL remodeling shapes a tissue specific pool of CL species. A wide variety of hetero-acylated CL species is found in most tissues, whereas in heart tetralinoleoyl-CL predominates. It is currently unresolved why mitochondrial function in cardiac tissue requires a specif

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