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br FOXP is an important transcription factor controlling di
2020-07-31
FOXP3 is an important transcription factor controlling differentia-tion and function of Tregs and is found in tumors like PC and melanoma (Karanikas et al., 2008). The role of FOXP3 in cancer has been reported especially in PC: this tumor can accumulate Tregs in/near the tumor and may ruin the immu
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Relebactam br Mar C reduces tumor growth
2020-07-30
3.2. Mar-C reduces tumor growth potential and prolongs the survival of tumor bearing mice To determine whether Mar-C had effects on tumor growth due to the induction of cancer cell senescence in vivo, human A549-luc xenografts (A549 Relebactam expressing luciferase) were developed in mice. As
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Tadalafil br Altered responses to EGF stimulation are the
2020-07-28
Altered responses to EGF stimulation are the potential results of network topology modulations (Koseska and Bastiaens, 2017; Santos et al., 2007) that are induced by POI abundance changes. To verify this, we focused on two pairs of EGF-induced shape-switching relationships, KSR2 to p-MAPKAPK
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br Low percentages of most
2020-07-26
Low percentages of most d-amino acids were observed in MCF-7 compared to MCF-10A cells. It was mostly due to the high lev-els of l-amino acids in MCF-7 cells, as the corresponding d-amino acid levels were not much different between these two cell lines (Figs. 4 and 5). However, significantly high
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br Margin of error Agreement Underestimation Overestimation
2020-07-04
Margin of error Agreement % (Underestimation, Overestimation) Mamm (Reader A) Tomo (Reader A) Mamm (Reader A) Tomo (Reader B) Note: Percentages may not sum to 100% due to rounding. a Analysis 1 compares measurements within a single reader; Analysis 2 compares measurements between two re
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br Pneumonitis is a rare but life threatening immune related
2020-07-04
Pneumonitis is a rare but life-threatening immune-related adverse effect.22 In our analysis of association with overall survival after the ED visit, pneumonitis was associated with poor survival (HR 1.72; 95% CI 1.03 to 2.87). In contrast, patients who developed colitis had better overall survival
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br The medical records of patients with NSCLC who had
2020-03-24
The medical records of patients with NSCLC who had undergone lung resection at Shanghai Chest Hospital between January 2008 and December 2014 were reviewed retrospectively. NSCLC staging was performed according to the 8th edition of the TNM classification [16]. Inclusion criteria were patients wit
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br Materials and methods br Human
2020-03-24
2. Materials and methods Human colon cancer cell lines HCT116 and HT29 (ATCC, Rockville, MD, USA) were maintained in DMEM supplemented with 10% fetal bovine serum (FBS; Thermo Fisher Scientific, Waltham, MA, USA) at 37 °C in 5% CO2. Vemurafenib-resistant sublines, designated HCT116-vemurafenib
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Cytochalasin D br Reports showed that ER ubiquitination modu
2020-03-24
Reports showed that ERα ubiquitination modulation by E3 ligases or deubiquitinases significantly changed ERα expression and its func-tion. There are three possible situations regarding ERα protein stability and transcriptional activity for ERα target genes: (a) increased ERα stability and transcri
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br In addition to the liver
2020-03-17
In addition to the liver-derived cancers, the trend of a decrease in tissue-specific SP gene expression generally held true among the other cancers (Figures 4 and S3), all of which exhibited either a significant coordinated decrease or no significant change in the genes specific to their res
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br We have previously developed and optimized in
2020-03-17
We have previously developed and optimized in situ proximity liga-tion assay (PLA) and solid-phase PLA for single protein detection as well as for detection of protein post-translational modification such as glyco-sylation and phosphorylation, which have been applied in GC tissue and serum specime
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br Conflict of Interest Statement br A R
2020-03-17
Conflict of Interest Statement A.R. has received funding from Varian Medical Systems, Boehringer Ingelheim, Pfizer, and AstraZeneca. All other The Journal of Thoracic and Cardiovascular Surgery c Volume 157, Number 1 371 Thoracic: Lung Cancer: Review Cao et al THOR authors have not
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iframe width height src https www youtube com
2019-11-12
Empowerment was the primary outcome in this RCT, defined as a multidimensional construct that, in the cancer context, refers to an “individual’s feelings of being able to manage the challenges of the cancer experience and of having a sense of control over one’s life” [[34], p. 3228]. It was ass
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br We would like to point
2019-11-11
We would like to point out that Pyocyanin the results obtained here using the adaptive moving mesh finite difference method qualitatively agree with the results of [5,22]. Note that for the results presented here we use less than 50% fewer grid points than that used in [5,22] which can help to red
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br Contents and Functionalities br Three patients asked for
2019-11-06
Contents and Functionalities Three patients asked for PKF118-310 with therapeutic prescriptions, also with reminders, and results of laboratory tests: “It would be interesting to add as a new functionality the therapy prescriptions, with reminders notified to patients.” [PA] “It would be